Tim-1 regulates Th2 responses in an airway hypersensitivity model

Orally administered β-glucan attenuates the Th2 response in a model of airway hypersensitivity

β-Glucan is a polysaccharide that can be extracted from fungal cell walls. Wellmune WGP(®), a preparation of β-1,3/1,6-glucans, is a dietary supplement that has immunomodulating properties. Here we investigated the effect WGP had on a mouse model of asthma. OVA-induced asthma in mice is characterized by infiltration of eosinophils into the lung, production of Th2 cytokines and IgE. Daily oral a...

TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells Short title: Role of TIM-1 and TIM-3 in mast cell function

Members of the T cell immunoglobulinand mucin-domain-containing molecule (TIM) family have roles in T cell-mediated immune responses. TIM-1 and TIM-2 are predominantly expressed on Th2 cells, whereas TIM-3 is preferentially expressed on Th1 and Th17 cells. We found that TIM-1 and TIM-3, but neither TIM-2 nor TIM-4, were constitutively expressed on mouse peritoneal mast cells and bone-marrow-der...

Complement C3a regulates Muc5ac expression by airway Clara cells independently of Th2 responses.

RATIONALE The factors that control the secretion of epithelial mucins are essential to understanding obstructive airway diseases such as asthma. Although the complement anaphylatoxin C3a and its receptor have been shown to promote many features of allergic lung inflammation, the contribution to mucin expression has not been elucidated. OBJECTIVES To determine if the C3a receptor with its liga...

Complement C3a Regulates Muc5ac Expression by Airway Clara Cells Independent of TH2 Responses

Independent of TH2 Responses Patricia Dillard, Rick A. Wetsel, and Scott M. Drouin The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases and Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, TX 77030 USA Correspondence and reprint requests should be addressed to Scott M. Drouin, Ph.D., The Bro...

Disease Differentiation, in a Model of Allergic Airway Th2-Mediated Inflammation, but Not Th2 Inducible Costimulator Regulates